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Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal mediator that plays a role in the development and enlargement of the prostate gland. Dutasteride was approved by the FDA in 2001 for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men as monotherapy or in combination with the α-adrenergic antagonist tamsulosin to enhance the therapeutic response. Its clinical efficacy against benign prostate hyperplasia in male patients is comparable to that of finasteride, a specific type II 5α-reductase inhibitor. However, unlike finasteride, Dutasteride is not yet indicated for the treatment of androgenic alopecia although it was demonstrated to be effective in several randomized, double-blind, placebo-controlled trials in androgenetic alopecia.

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Dutasteride is used alone or with another medication (tamsulosin [Flomax]) to treat benign prostatic hyperplasia (BPH; enlargement of the prostate gland). Dutasteride is used to treat symptoms of BPH and may reduce the chance of developing acute urinary retention (sudden inability to urinate). Dutasteride may also decrease the chance that prostate surgery will be needed. Dutasteride is in a class of medications called 5-alpha reductase inhibitors. It works by blocking the production of a natural substance that enlarges the prostate.

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The cytokines effect on EBV-immortalized human B cells producing antisperm antibody. Serial (18)F-FDG PET and apparent diffusion coefficient (ADC) maps derived from DW-MR images of NCI-H460 xenograft tumors were coregistered, and a population-based GMM was implemented on the complementary imaging data. The shift from surgical to radiological intervention was recently reported in retrospective cohort studies, but it has remained controversial as to which emergent intervention provides optimal management. We found no difference in histopathologic features and outcomes between men and women treated with RNU for UTUC. Tiropramide at the lower concentrations did not affect cAMP and cGMP levels in the smooth muscles of the urethra, stomach and intestines.

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A pulse sequence is then generated which will yield the desired Mz(f) and Mxy(f). The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism.

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We compared tumor necrosis factor (TNF) metabolism by wild-type MCF-7 (WT) cells, by 40-fold doxorubicin resistant (40F) breast cancer cells and by PC3 and LNCaP prostate cancer cell lines. The most recent relevant research advances on glucose metabolism, liver function, cardiac function, renal function, sepsis, inflammation, infection, anaphylaxis and hormonal aspect are hereby reviewed.

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Multiple DNA rearrangements in the BCL2 region in a patient with follicular lymphoma. Oral disease status of a sample of Jordanian people ages 10 to 28 with cleft lip and palate.

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The activating D816V mutation of Kit, seen in the majority of mastocytosis patients, causes a robust activation of PI3K signals. Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. There are many unsolved questions and many studies have to be performed to understand the overall function of the TRPM family.

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Mental stress and immunological abnormality have recently been listed as causes of alopecia universalis. We investigated the effect of the antiviral drug amantadine (AmTd) on polyclonal activation of thymic-dependent (T) and thymic-independent (B) lymphocytes from normal mice. Case 1: abdominal pain, vomiting, and weakness in an obese adolescent. In the preintervention cohort from July 1, 2011, to December 31, 2011, probiotics were not used. Results on painful symptoms were excellent in 9 cases and good in 3.

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Gaining weight together with menopausal endocrine changes cause metabolic and hemodynamic imbalances, which contribute to risk for cardiovascular diseases. Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells.

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Overall, our findings suggest that the sensitivity of tumor cell lines to DHA involves oxidized metabolites. The healing progressed so that the symptoms completely resolved within a year after the treatment. Development of a new direct liquid injection system for nanoparticle deposition by chemical vapor deposition using nanoparticle solutions. It has been shown clinically that the healing processes encountered at the site of a subperiosteal implant which is implanted as a sustainer for dentures is greatly dependent on the method of fixation.

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Our results warrant further characterization of split helper Sindbis virus vectors and imply their utility in gene therapy approaches where spreading of transgene expression and consequently high gene transfer rate could be beneficial. Application of biological samples treated by wet-digested mineralization to cation-exchange high-performance liquid chromatography with post-column reaction by 4-(2-pyridylazo)-resorcinol. Data analysis included correlation coefficients and multiple linear regression. The essential therapy is the injection of local anesthetic and a small dose of corticoid into the precise focal point of hyperirritability deep in the belly of the muscle.

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This review provides a summary of the developments and approaches that were used in our group in order to improve the power conversion efficiency of DSSCs and BHJs based on porphyrin hybrid derivatives. While interventions proven efficacious in stable settings are being used in humanitarian efforts, more evidence is required to demonstrate the effectiveness of delivering and scaling-up such interventions in humanitarian crises. Pretreatment, posttreatment, and most recent Cobb angle, sagittal balance, and spinal length, were measured to assess overall curve correction. Pulmonary edema and cardiac dysfunction after resection of a fourth ventricle tumor in a toddler: case report.

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Entomologic data from two former endemic river basins in North Cameroon were generated over a period of 43 and 48 months to follow-up transmission levels in areas under prolonged ivermectin control. The main goal of this study was to evaluate the use of Mycobacterium bovis recombinant 32-kDa protein (r32-kDa) antigen-stimulated T-cell assay as a surrogate marker for treatment outcome and monitor vitamin D receptor (VDR)-mediated anti-microbial responses during multidrug therapy (MDT) in leprosy.

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Significant cerebral blood flow reductions were observed following sagittal but not coronal or horizontal injury compared to sham. Use of some tests for the assessment of reactions of dental pulp in permanent anterior teeth in children aged 7-11 A case of brainstem infarction presenting with paralytic pontine exotropia and non-paralytic pontine exotropia

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Seven clonal strains of Gambierdiscus toxicus isolated from three ciguateric areas around Tahiti island were mass cultured and extracted for ciguatoxins and maitotoxin. Differential diagnosis and prognosis of T1-weighted post-gadolinium intralabyrinthine hyperintensities. Circulating PD-1/PD-L1 expression was associated with severity of diseases in patients with HCC, and the circulating PD-L1 expression was closely correlated with intratumoral PD-L1 expression. Further, fibroblasts transfected with the human leukosialin cDNA gain reactivity to these mAb, showing conclusively that molecules recognized by these mAb are determined by the same cDNA. No particular quantitative alteration of the electrophoretic profile of outer membrane proteins could be associated with the period of isolation and geographic origin of the isolates.

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Energy expenditure during level human walking: seeking a simple and accurate predictive solution. Cell fractionation experiments revealed that nuclear EGFR was significantly diminished in ezrin-knockdown cells. The effect of food or milk on the absorption kinetics of ofloxacin.

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Arterial hypertension as a risk factor for ischemic heart disease in women--results from a retrospective and from a prospective study. Furthermore, the distances of the carbons C1 and C2 of L-ribose to the catalytic metal M2 were higher than in the case of D-xylose. Histological changes in the genital tract of female veal calves implanted with naturally occurring anabolic steroids. Severely involved teeth were allowed to exfoliate, and extractions were avoided. The potentially pathogenic microorganism obtained in the sputum culture depends on the associated comorbidities.

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Prostate cancer is second most common cancer in men overall in the world, whereas it is the third most common cancer in men and the sixth most common cancer in Iran. The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume.

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Characterization of a gamma-carboxyglutamic acid-containing protein from bone. Amygdalar catecholaminergic input to septal nuclei, relation to clomipramine actions on lateral septal neurons in the rat.

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Adaptive mechanisms of striatal D1 and D2 dopamine receptors in response to a prolonged reserpine treatment in mice. Simulation results indicate that multiple-focus scanning not only provides an alternative to single-focus scanning, but also achieves better localization in the heating pattern. TN-912 (30 mg/kg) had little effect on lead II electrocardiogram (ECG), while IMP and MPT markedly increased height of the T-wave on ECG. Further studies will be necessary to define whether other lipid abnormalities occur and the biologic significance of these findings. (Ornithischia: Thyreophora) from the Lower Cretaceous Allaru Mudstone of Richmond, Queensland, Australia.

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Two metalloproteinases, a 24-kDa P-I EoVMP1 and a 56-kDa P-III EoVMP2, have recently been isolated from the venom of the West African motosega potatura zomax pill saw-scaled viper Echis ocellatus. The findings indicate that antenatal nursing intervention is a potentially protective measure for perinatal emotional well-being. We prepared a column of human erythrocyte band 3 carbohydrate glycopeptide (erythroglycan) attached to Sepharose as an affinity matrix. New York Nurses Association certification: its history and progress. Chronic ethanol administration significantly decreased the percentage of arachidonate and significantly increased the linoleate: arachidonate ratio in the cortical synaptosomal phosphatidylinositol (PI) of rats.

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Editorial comment: failure of HAART to reconstitute CMV-specific protective immunity. This study supports the hypothesis that inflammation of EAT around the LA, but not SAT, is related to the presence of PAF. The findings of thin-section high-resolution CT of the temporal bone in two children with Johanson-Blizzard syndrome are reported. Factors associated with compliance with the lovir 800 mg recommended frequency of postnatal care services in three rural districts of Tanzania. CMV infections following allogeneic BMT: risk factors, early treatment and correlation with transplant related mortality.